University of California San Francisco

Tobias Deuse, MD

Dr. Tobias Deuse
Tobias Deuse, MD

Professor of Surgery
The Julien I.E. Hoffman, M.D. Endowed Chair in Cardiac Surgery
Principal Investigator, TSI Lab
Division of Cardiac Surgery & Lung Transplantation
Department of Surgery, School of Medicine
University of California, San Francisco
Director, Minimally-Invasive Cardiac Surgery, UCSF Health
Surgical Director, Transcatheter Valve Program, UCSF Health
 

Academic Office:
500 Parnassus Ave, MUW 405, Box 0118
San Francisco, CA 94143-0118
Tel: (415) 353-8890
Email: Tobias.Deuse@ucsf.edu 
Admin: Krislyn.Malagum@ucsf.edu 

Cardiac Surgery Program
400 Parnassus Avenue, Suite 501, Box 0957
San Francisco, California,  94143
Tel:415-353-1606
Fax: 415-353-1312

Biography

Dr. Tobias Deuse is a heart surgeon and the director of minimally invasive cardiac surgery at UCSF. He is known for his pioneering work in developing minimally invasive techniques for mitral valve repair.

Deuse earned his medical degree from the University of Würzburg in Germany. He received advanced training in heart and lung surgery at the University Hospital of Munich and University Heart Center Hamburg. After obtaining board certification in Germany as a heart surgeon, he completed a fellowship in lung and heart-lung transplantation with Stanford Medicine.

After returning to Germany in 2009, Deuse was appointed director of heart and lung transplantation at the University Heart Center Hamburg. He achieved international acclaim for his development of innovative approaches to heart failure surgery, most notably minimally invasive techniques for implanting ventricular assist systems. He also demonstrated that high success rates could be achieved in mitral valve repair utilizing fully robot-assisted endoscopic surgery. Also known as keyhole surgery, this approach has many benefits for the patient, including substantially reduced postsurgical pain, shorter hospital stays and faster recovery.

Deuse has received numerous honors, including election to the board of directors of the International Society for Heart and Lung Transplantation.

Education

Institution Degree Dept or School End Date
University of California Diversity, Equity, and Inclusion Champion Training 2019

Collaboration Interests

I am interested in:

  • physician scientist

Clinical Expertise

Minimally Invasive Mitral Valve Surgery

Minimally Invasive Aortic Valve Surgery

Minimally Invasive Atrial Septal Defect (ASD) Closure

Aortic Valve Repair & Replacement

Acute Aortic Dissection Repair

Heart Transplantation

Lung Transplantation

Ventricular Assist Devices (VAD)

Ventricular Aneurysm

Arrhythmia

Coronary Artery Bypass Grafting (CABG)

Off-Pump Coronary Artery Bypass (OPCAB)

Program Affiliations

UCSF Heart & Vascular Center

In the News

The Economist: New treatments are emerging for type-1 diabetes
February, 20, 2024 | The Economist
Dr. Tobias Deuse Awarded 4-year NSF Grant to Study Effects of Aging Aboard ISS Using Novel Platform
October, 04, 2019 | Transplant and Stem Cell Immunobiology (TSI) Lab
Tobias Deuse, MD and Sonja Schrepfer, MD, PhD Lead Research Team Unearthing New Clues to Stem Cell Transplant Rejection
August, 20, 2019 | UCSF News
CRISPR Gene Editing Makes Stem Cells ‘Invisible’ to Immune System
February, 26, 2019 | Transplant and Stem Cell Immunobiology (TSI) Lab
Sonja Schrepfer, MD, PhD and Tobias Deuse, MD Awarded 4-Year $3M NIH R01 Grant to Study Role of Cardiomyocytes in Heart Repair
December, 05, 2018 | Transplant and Stem Cell Immunobiology (TSI) Lab
Sonja Schrepfer and Tobias Deuse Awarded 4-year $2.4M NIH Grant to Study Space-Related Physiological Changes and Altered Immune Function
February, 26, 2018 | Transplant and Stem Cell Immunobiology (TSI) Lab
Tobias Deuse, M.D., Named The Julien I. E. Hoffman, M.D. Chair in Cardiac Surgery
January, 26, 2018 | UCSF Cardiothoracic Surgery
Traveling to Mars Will Wreak Havoc on Our Bodies — Can We Prevent It?
August, 14, 2017 | UCSF Vascular & Endovascular Surgery
Sonja Schrepfer Receives CIRM Grant to Develop Hypo-Immunogenic Cardiac Patches for Myocardial Regeneration
June, 16, 2017 | UCSF Adult CT, Transplant and Stem Cell Biology (TSI) Lab
Transplant and Stem Cell Immunobiology (TSI) Lab Launches New Website
November, 18, 2016 | UCSF Department of Surgery

Grants and Funding

  • Hypo-immunogenic cardiomyocytes for myocardial repair | NIH | 2018-08-01 - 2022-06-30 | Role: Principal Investigator
  • Microgravity as model for immunological senescence and its impact on tissue stem cells and regeneration | NIH | 2017-06-15 - 2022-06-30 | Role: Co-Principal Investigator
  • Microgravity as model for immunological senescence and its impact on tissue stem cells and regeneration | NIH | 2017-06-15 - 2020-02-29 | Role: Co-Principal Investigator

Research Narrative

Dr. Deuse's research is focused on vascular biology and pathophysiology. His group was the among the first to elucdiate the novel pathways involved in the development of vascular intimal hyperplasia. Myointimal hyperplasia is a pathological process of the vascular system characterized by abnormal proliferation of smooth muscle cells of the vascular wall that leads to luminal obliteration and subsequent ischemia.

Myointimal hyperplasia may occur in patients after vessel injury during medical procedures (e.g. after balloon dilation or stent placement) or after pathological injury of the blood vessel (e.g. due to inflammation or toxic exposure). It can cause bypass graft failure and in-stent restenosis. To help prevent this and increase the success of treatments for vascular disease including coronary heart disease, his research group is working on the development of new preventive drug regimes and strategies.

Research Interests

Vascular Biology

Stem Cell Immunobiology

Transplant Immunology

Oxidative Stress and Apoptosis

Pulmonary Hypertension

Publications

MOST RECENT PUBLICATIONS FROM A TOTAL OF 145
  1. Inhibition of polymorphonuclear cells averts cytotoxicity against hypoimmune cells in xenotransplantation.
    Hu X, Tediashvili G, Gravina A, Stoddard J, McGill TJ, Connolly AJ, Deuse T, Schrepfer S| | PubMed
  2. Progress and challenges in developing allogeneic cell therapies.
    Deuse T, Schrepfer S| | PubMed
  3. Hydroxocobalamin for the treatment of vasoplegia after lung transplantation: A case series.
    Nguyen A, Bouajram R, Brzezinski M, Hassanipour S, Gordon D, Trinh B, Deuse T, Venado A, Hays S, Singer J, Kukreja J| | PubMed
  4. The HIP mouse and all of its organs are completely invisible to allogeneic immune cells.
    Hu X, White K, Olroyd AG, Wang C, Caruso CB, Gattis C, Young C, Connolly AJ, Deuse T, Schrepfer S| | PubMed
  5. Clinical Improvement With Transcatheter Edge-to-Edge Tricuspid Repair Irrespective of Right Atrial Pressure.
    Ya'Qoub L, Caughron H, Qasim A, Tolstrop K, Delling FN, Watt C, Nguyen T, Deuse T, Beygui RE, Mahadevan VS| | PubMed
  6. Hypoimmune islets achieve insulin independence after allogeneic transplantation in a fully immunocompetent non-human primate.
    Hu X, White K, Young C, Olroyd AG, Kievit P, Connolly AJ, Deuse T, Schrepfer S| | PubMed
  7. Four decades of progress in heart-lung transplantation: Two hundred seventy-one cases at a single institution.
    Elde S, Baccouche BM, Mullis DM, Leipzig MM, Deuse T, Krishnan A, Fawad M, Dale R, Walsh S, Padilla-Lopez A, Wesley B, He H, Yajima S, Zhu Y, Wang H, Guenthart BA, Shudo Y, Reitz BA, Woo YJ| | PubMed
  8. Lung Transplantation in Patients with Cystic Fibrosis: A Complex Task, A Changing Target.
    Loebe M, Deuse T, Sinha N, Koster A, Erdoes G| | PubMed
  9. Synthetic immune checkpoint engagers protect HLA-deficient iPSCs and derivatives from innate immune cell cytotoxicity.
    Gravina A, Tediashvili G, Zheng Y, Iwabuchi KA, Peyrot SM, Roodsari SZ, Gargiulo L, Kaneko S, Osawa M, Schrepfer S, Deuse T| | PubMed
  10. Hypoimmune induced pluripotent stem cells survive long term in fully immunocompetent, allogeneic rhesus macaques.
    Hu X, White K, Olroyd AG, DeJesus R, Dominguez AA, Dowdle WE, Friera AM, Young C, Wells F, Chu EY, Ito CE, Krishnapura H, Jain S, Ankala R, McGill TJ, Lin A, Egenberger K, Gagnon A, Michael Rukstalis J, Hogrebe NJ, Gattis C, Basco R, Millman JR, Kievit P, Davis MM, Lanier LL, Connolly AJ, Deuse T, Schrepfer S| | PubMed
  11. Human hypoimmune primary pancreatic islets avoid rejection and autoimmunity and alleviate diabetes in allogeneic humanized mice.
    Hu X, Gattis C, Olroyd AG, Friera AM, White K, Young C, Basco R, Lamba M, Wells F, Ankala R, Dowdle WE, Lin A, Egenberger K, Rukstalis JM, Millman JR, Connolly AJ, Deuse T, Schrepfer S| | PubMed
  12. Hypoimmune anti-CD19 chimeric antigen receptor T cells provide lasting tumor control in fully immunocompetent allogeneic humanized mice.
    Hu X, Manner K, DeJesus R, White K, Gattis C, Ngo P, Bandoro C, Tham E, Chu EY, Young C, Wells F, Basco R, Friera A, Kangeyan D, Beauchesne P, Dowdle WE, Deuse T, Fry TJ, Foster AE, Schrepfer S| | PubMed
  13. Protection of cell therapeutics from antibody-mediated killing by CD64 overexpression.
    Gravina A, Tediashvili G, Rajalingam R, Quandt Z, Deisenroth C, Schrepfer S, Deuse T| | PubMed
  14. Morbidity and Mortality Associated With Blood Transfusions in Elective Adult Cardiac Surgery.
    Sanaiha Y, Hadaya J, Verma A, Shemin RJ, Madani M, Young N, Deuse T, Sun J, Benharash P, University of California Cardiac Surgery Consortium| | PubMed
  15. Author Correction: Hypoimmunogenic derivatives of induced pluripotent stem cells evade immune rejection in fully immunocompetent allogeneic recipients.
    Deuse T, Hu X, Gravina A, Wang D, Tediashvili G, De C, Thayer WO, Wahl A, Garcia JV, Reichenspurner H, Davis MM, Lanier LL, Schrepfer S| | PubMed
  16. Intercostal Nerve Cryoanalgesia Versus Thoracic Epidural Analgesia in Lung Transplantation: A Retrospective Single-Center Study.
    Isaza E, Santos J, Haro GJ, Chen J, Weber DJ, Deuse T, Singer JP, Golden JA, Hays S, Trinh BN, Brzezinski M, Kukreja J| | PubMed
  17. Hypoimmune induced pluripotent stem cell-derived cell therapeutics treat cardiovascular and pulmonary diseases in immunocompetent allogeneic mice.
    Deuse T, Tediashvili G, Hu X, Gravina A, Tamenang A, Wang D, Connolly A, Mueller C, Mallavia B, Looney MR, Alawi M, Lanier LL, Schrepfer S| | PubMed
  18. Shock, Thrombus, TAVR: A Challenging TAVR With Large Left-Ventricular Thrombus.
    Blusztein D, Teng P, Deuse T, Mahadevan VS| | PubMed
  19. Immunomodulation Therapy Using Tolerogenic Macrophages in a Rodent Model of Pulmonary Hypertension.
    Guihaire J, Deuse T, Wang D, Spin JM, Blankenberg FG, Fadel E, Reichenspurner H, Schrepfer S| | PubMed
  20. The SIRPα-CD47 immune checkpoint in NK cells.
    Deuse T, Hu X, Agbor-Enoh S, Jang MK, Alawi M, Saygi C, Gravina A, Tediashvili G, Nguyen VQ, Liu Y, Valantine H, Lanier LL, Schrepfer S| | PubMed
  21. Outcomes of transcatheter aortic valve replacement in end stage liver and renal disease.
    Caughron H, Parikh D, Allison Z, Deuse T, Mahadevan VS| | PubMed
  22. Subxiphoid Hybrid Epicardial-Endocardial Atrial Fibrillation Ablation and LAA Ligation: Initial Sub-X Hybrid MAZE Registry Results.
    Ellis CR, Badhwar N, Tschopp D, Danter M, Jackson GG, Kerendi F, Walters T, Fang Q, Deuse T, Beygui R, Lee RJ| | PubMed
  23. Impact of Aortic Stenosis on Myofiber Stress: Translational Application of Left Ventricle-Aortic Coupling Simulation.
    Wisneski AD, Wang Y, Deuse T, Hill AC, Pasta S, Sack KL, Yao J, Guccione JM| | PubMed
  24. The H-Y Antigen in Embryonic Stem Cells Causes Rejection in Syngeneic Female Recipients.
    Hu X, Kueppers ST, Kooreman NG, Gravina A, Wang D, Tediashvili G, Schlickeiser S, Frentsch M, Nikolaou C, Thiel A, Marcus S, Fuchs S, Velden J, Reichenspurner H, Volk HD, Deuse T, Schrepfer S| | PubMed
  25. Risk Factors and Outcomes of Extracorporeal Membrane Oxygenation as a Bridge to Lung Transplantation.
    Kukreja J, Tsou S, Chen J, Trinh BN, Feng C, Golden JA, Hays S, Deuse T, Singer JP, Brzezinski M| | PubMed
  26. Frailty after lung transplantation is associated with impaired health-related quality of life and mortality.
    Venado A, Kolaitis NA, Huang CY, Gao Y, Glidden DV, Soong A, Sutter N, Katz PP, Greenland JR, Calabrese DR, Hays SR, Golden JA, Shah RJ, Leard LE, Kukreja J, Deuse T, Wolters PJ, Covinsky K, Blanc PD, Singer JP| | PubMed
  27. Impact of donor lung quality on post-transplant recipient outcome in the Lung Allocation Score era in Eurotransplant - a historical prospective study.
    Smits JM, Gottlieb J, Verschuuren E, Evrard P, Hoek R, Knoop C, Lang G, Kwakkel-van Erp JM, Vos R, Verleden G, Rondelet B, Hoefer D, Langer F, Schramm R, Hoetzenecker K, van Kessel D, Luijk B, Seghers L, Deuse T, Buhl R, Witt C, Strelniece A, Green D, de Vries E, Laufer G, Van Raemdonck D| | PubMed
  28. A Cryoinjury Model to Study Myocardial Infarction in the Mouse.
    Wang D, Tediashvili G, Hu X, Gravina A, Marcus SG, Zhang H, Olgin JE, Deuse T, Schrepfer S| | PubMed
  29. De novo mutations in mitochondrial DNA of iPSCs produce immunogenic neoepitopes in mice and humans.
    Deuse T, Hu X, Agbor-Enoh S, Koch M, Spitzer MH, Gravina A, Alawi M, Marishta A, Peters B, Kosaloglu-Yalcin Z, Yang Y, Rajalingam R, Wang D, Nashan B, Kiefmann R, Reichenspurner H, Valantine H, Weissman IL, Schrepfer S| | PubMed
  30. Bergeyella cardium: Clinical Characteristics and Draft Genome of an Emerging Pathogen in Native and Prosthetic Valve Endocarditis.
    Mulliken JS, Langelier C, Budak JZ, Miller S, Dynerman D, Hao S, Li LM, Crawford E, Lyden A, Woodworth MH, DeRisi JL, Desmond E, Browne C, Luu A, Grandis DJ, Grossman W, Deuse T, Melcher GP| | PubMed
  31. Hypoimmunogenic derivatives of induced pluripotent stem cells evade immune rejection in fully immunocompetent allogeneic recipients.
    Deuse T, Hu X, Gravina A, Wang D, Tediashvili G, De C, Thayer WO, Wahl A, Garcia JV, Reichenspurner H, Davis MM, Lanier LL, Schrepfer S| | PubMed
  32. Nontyphoidal Salmonella as a Cause of Mediastinal Abscess after Aortic Valve Replacement: A Case Report and Review of Postoperative Salmonella Infections.
    Spottiswoode N, Peluso MJ, Deuse T, Babik JM| | PubMed
  33. Analysis of Minimally Invasive Left Thoracotomy HVAD Implantation - A Single-Center Experience.
    Reichart D, Brand CF, Bernhardt AM, Schmidt S, Schaefer A, Blankenberg S, Reichenspurner H, Wagner FM, Deuse T, Barten MJ| | PubMed
  34. Lung allocation score: the Eurotransplant model versus the revised US model - a cross-sectional study.
    Smits JM, Nossent G, Evrard P, Lang G, Knoop C, Kwakkel-van Erp JM, Langer F, Schramm R, van de Graaf E, Vos R, Verleden G, Rondelet B, Hoefer D, Hoek R, Hoetzenecker K, Deuse T, Strelniece A, Green D, de Vries E, Samuel U, Laufer G, Buhl R, Witt C, Gottlieb J| | PubMed
  35. Normothermic ex-vivo preservation with the portable Organ Care System Lung device for bilateral lung transplantation (INSPIRE): a randomised, open-label, non-inferiority, phase 3 study.
    Warnecke G, Van Raemdonck D, Smith MA, Massard G, Kukreja J, Rea F, Loor G, De Robertis F, Nagendran J, Dhital KK, Moradiellos Díez FJ, Knosalla C, Bermudez CA, Tsui S, McCurry K, Wang IW, Deuse T, Lesèche G, Thomas P, Tudorache I, Kühn C, Avsar M, Wiegmann B, Sommer W, Neyrinck A, Schiavon M, Calabrese F, Santelmo N, Olland A, Falcoz PE, Simon AR, Varela A, Madsen JC, Hertz M, Haverich A, Ardehali A| | PubMed
  36. Hybrid Open Minimally Invasive Transcatheter Mitral Valve Replacement.
    Marcus SG, Mahadevan VS, Deuse T| | PubMed
  37. Balloon-based Injury to Induce Myointimal Hyperplasia in the Mouse Abdominal Aorta.
    Tediashvili G, Wang D, Reichenspurner H, Deuse T, Schrepfer S| | PubMed
  38. Hybrid and surgical procedures for the treatment of persistent and longstanding persistent atrial fibrillation.
    Sanchez JM, Al-Dosari G, Chu S, Beygui R, Deuse T, Badhwar N, Lee RJ| | PubMed
  39. Outcomes of Minimally Invasive Temporary Right Ventricular Assist Device Support for Acute Right Ventricular Failure During Minimally Invasive Left Ventricular Assist Device Implantation.
    Schaefer A, Reichart D, Bernhardt AM, Kubik M, Barten MJ, Wagner FM, Reichenspurner H, Philipp SA, Deuse T| | PubMed
  40. Thalidomide treatment prevents chronic graft rejection after aortic transplantation in rats - an experimental study.
    Miller KK, Wang D, Hu X, Hua X, Deuse T, Neofytou E, Renne T, Velden J, Reichenspurner H, Schrepfer S, Bernstein D| | PubMed
  41. Differences in Vascular Response between Balloon Overstretch and Stent Overexpansion in Nonatherosclerotic Porcine Coronary Arteries.
    Mitsutake Y, Reifart J, Pyun WB, Lyons JK, Deuse T, Schrepfer S, Ikeno F| | PubMed
  42. Gender differences and outcomes in left ventricular assist device support: The European Registry for Patients with Mechanical Circulatory Support.
    Magnussen C, Bernhardt AM, Ojeda FM, Wagner FM, Gummert J, de By TMMH, Krabatsch T, Mohacsi P, Rybczynski M, Knappe D, Sill B, Deuse T, Blankenberg S, Schnabel RB, Reichenspurner H| | PubMed
  43. The value of fluorine-18 deoxyglucose positron emission tomography scans in patients with ventricular assist device specific infections†.
    Bernhardt AM, Pamirsad MA, Brand C, Reichart D, Tienken M, Barten MJ, Schaefer A, Grahn H, Rybczynski M, Deuse T, Reichenspurner H, Wagner FM| | PubMed
  44. Lobar lung transplantation from deceased donors: A systematic review.
    Eberlein M, Reed RM, Chahla M, Bolukbas S, Blevins A, Van Raemdonck D, Stanzi A, Inci I, Marasco S, Shigemura N, Aigner C, Deuse T| | PubMed
  45. Vein Interposition Model: A Suitable Model to Study Bypass Graft Patency.
    Wang D, Tediashvili G, Pecha S, Reichenspurner H, Deuse T, Schrepfer S| | PubMed
  46. Orthotopic tracheal transplantation using human bronchus: an original xenotransplant model of obliterative airway disorder.
    Guihaire J, Itagaki R, Stubbendorff M, Hua X, Deuse T, Ullrich S, Fadel E, Dorfmüller P, Robbins RC, Reichenspurner H, Schumacher U, Schrepfer S| | PubMed
  47. Acute Pulmonary Artery Obstruction as the Primary Manifestation of a Rapidly Growing Intimal Sarcoma in a 54-Year-Old Patient.
    Westhofen S, Kugler C, Reichenspurner H, Deuse T| | PubMed
  48. A matched pairs analysis of non-rib-spreading, fully endoscopic, mini-incision technique versus conventional mini-thoracotomy for mitral valve repair.
    Westhofen S, Conradi L, Deuse T, Detter C, Vettorazzi E, Treede H, Reichenspurner H| | PubMed
  49. The Selective JAK1/3-Inhibitor R507 Mitigates Obliterative Airway Disease Both With Systemic Administration and Aerosol Inhalation.
    Deuse T, Hua X, Stubbendorff M, Spin JM, Neofytou E, Taylor V, Chen Y, Park G, Fink JB, Renne T, Kiefmann M, Kiefmann R, Reichenspurner H, Robbins RC, Schrepfer S| | PubMed
  50. The MANDELA study: A multicenter, randomized, open-label, parallel group trial to refine the use of everolimus after heart transplantation.
    Deuse T, Bara C, Barten MJ, Hirt SW, Doesch AO, Knosalla C, Grinninger C, Stypmann J, Garbade J, Wimmer P, May C, Porstner M, Schulz U| | PubMed
  51. Sex Differences in Immunology: More Severe Development of Experimental Pulmonary Hypertension in Male Rats Exposed to Vascular Endothelial Growth Factor Receptor Blockade.
    Guihaire J, Deuse T, Wang D, Fadel E, Reichenspurner H, Schrepfer S| | PubMed
  52. Distal Airway Stem Cells are Essential for Lung Regeneration.
    Deuse T, Schrepfer S| | PubMed
  53. Local MicroRNA Modulation Using a Novel Anti-miR-21-Eluting Stent Effectively Prevents Experimental In-Stent Restenosis.
    Wang D, Deuse T, Stubbendorff M, Chernogubova E, Erben RG, Eken SM, Jin H, Li Y, Busch A, Heeger CH, Behnisch B, Reichenspurner H, Robbins RC, Spin JM, Tsao PS, Schrepfer S, Maegdefessel L| | PubMed
  54. Mesenchymal stromal cell therapy: different sources exhibit different immunobiological properties.
    Neofytou E, Deuse T, Beygui RE, Schrepfer S| | PubMed
  55. Immunobiology of fibrin-based engineered heart tissue.
    Conradi L, Schmidt S, Neofytou E, Deuse T, Peters L, Eder A, Hua X, Hansen A, Robbins RC, Beygui RE, Reichenspurner H, Eschenhagen T, Schrepfer S| | PubMed
  56. Concomitant minimally invasive HVAD and transapical aortic valve implantation.
    Schaefer A, Treede H, Bernhardt A, Wagner FM, Reichenspurner H, Deuse T| | PubMed
  57. SCNT-derived ESCs with mismatched mitochondria trigger an immune response in allogeneic hosts.
    Deuse T, Wang D, Stubbendorff M, Itagaki R, Grabosch A, Greaves LC, Alawi M, Grünewald A, Hu X, Hua X, Velden J, Reichenspurner H, Robbins RC, Jaenisch R, Weissman IL, Schrepfer S| | PubMed
  58. Thymoglobulin induction in heart transplantation: patient selection and implications for maintenance immunosuppression.
    Zuckermann A, Schulz U, Deuse T, Ruhpawar A, Schmitto JD, Beiras-Fernandez A, Hirt S, Schweiger M, Kopp-Fernandes L, Barten MJ| | PubMed
  59. Isolated permanent right ventricular assist device implantation with the HeartWare continuous-flow ventricular assist device: first results from the European Registry for Patients with Mechanical Circulatory Support.
    Bernhardt AM, De By TM, Reichenspurner H, Deuse T| | PubMed
  60. Clinical experience of combined HeartWare ventricular assist device and implantable cardioverter defibrillator therapy.
    Pecha S, Wilke I, Bernhardt A, Hakmi S, Yildirim Y, Steven D, Reichenspurner H, Willems S, Deuse T, Aydin A| | PubMed
  61. HVAD implantation in right atrium-to-right pulmonary artery configuration.
    Deuse T, Kubik M, Reichenspurner H| | PubMed
  62. Introduction of the lung allocation score in Germany.
    Gottlieb J, Greer M, Sommerwerck U, Deuse T, Witt C, Schramm R, Hagl C, Strueber M, Smits JM| | PubMed
  63. Inducing myointimal hyperplasia versus atherosclerosis in mice: an introduction of two valid models.
    Stubbendorff M, Hua X, Deuse T, Ali Z, Reichenspurner H, Maegdefessel L, Robbins RC, Schrepfer S| | PubMed
  64. Dichloroacetate prevents restenosis in preclinical animal models of vessel injury.
    Deuse T, Hua X, Wang D, Maegdefessel L, Heeren J, Scheja L, Bolaños JP, Rakovic A, Spin JM, Stubbendorff M, Ikeno F, Länger F, Zeller T, Schulte-Uentrop L, Stoehr A, Itagaki R, Haddad F, Eschenhagen T, Blankenberg S, Kiefmann R, Reichenspurner H, Velden J, Klein C, Yeung A, Robbins RC, Tsao PS, Schrepfer S| | PubMed
  65. Minimally invasive implantation of biventricular assist devices.
    Deuse T, Reichenspurner H| | PubMed
  66. Do not touch the sternum--thoracotomy incisions for HVAD implantation.
    Deuse T, Reichenspurner H| | PubMed
  67. Efficacy of prophylactic intra-aortic balloon pump therapy in chronic heart failure patients undergoing cardiac surgery.
    Yildirim Y, Pecha S, Kubik M, Alassar Y, Deuse T, Hakmi S, Reichenspurner H| | PubMed
  68. Dual-chamber pacemaker implantation with left ventricular pacing in a patient with a right ventricular assist device.
    Sill B, Reichenspurner H, Deuse T| | PubMed
  69. HVAD continuous flow assist device for ischemic ventricular septal rupture.
    Bernhardt AM, Reichenspurner H, Deuse T| | PubMed
  70. Mechanically induced ventricular tachycardia by the HeartWare ventricular assist device.
    Yildirim Y, Pecha S, Reichenspurner H, Deuse T| | PubMed
  71. Everolimus in heart transplantation: an update.
    Hirt SW, Bara C, Barten MJ, Deuse T, Doesch AO, Kaczmarek I, Schulz U, Stypmann J, Haneya A, Lehmkuhl HB| | PubMed
  72. Bortezomib rescue therapy in a patient with recurrent antibody-mediated rejection after lung transplantation.
    Baum C, Reichenspurner H, Deuse T| | PubMed
  73. Granulocyte colony-stimulating factor therapy is associated with a reduced incidence of acute rejection episodes or allograft vasculopathy in heart transplant recipients.
    Vrtovec B, Haddad F, Pham M, Deuse T, Fearon WF, Schrepfer S, Leon S, Vu T, Valantine H, Hunt SA| | PubMed
  74. Immunological properties of extraembryonic human mesenchymal stromal cells derived from gestational tissue.
    Stubbendorff M, Deuse T, Hua X, Phan TT, Bieback K, Atkinson K, Eiermann TH, Velden J, Schröder C, Reichenspurner H, Robbins RC, Volk HD, Schrepfer S| | PubMed
  75. Minimal access median sternotomy for aortic valve replacement in elderly patients.
    Alassar Y, Yildirim Y, Pecha S, Detter C, Deuse T, Reichenspurner H| | PubMed
  76. Isolated permanent right ventricular assistance using the HVAD continuous-flow pump.
    Deuse T, Schirmer J, Kubik M, Reichenspurner H| | PubMed
  77. Aspergillus galactomannan antigen for diagnosis and treatment monitoring in cerebral aspergillosis.
    Soeffker G, Wichmann D, Loderstaedt U, Sobottka I, Deuse T, Kluge S| | PubMed
  78. ST-elevation myocardial infarction following heart transplantation as an unusual presentation of coronary allograft vasculopathy: a case report.
    Peter S, Hulme O, Deuse T, Vrtovec B, Fearon WF, Hunt S, Haddad F| | PubMed
  79. The potassium channel KCa3.1 as new therapeutic target for the prevention of obliterative airway disease.
    Hua X, Deuse T, Chen YJ, Wulff H, Stubbendorff M, Köhler R, Miura H, Länger F, Reichenspurner H, Robbins RC, Schrepfer S| | PubMed
  80. Severe bacterial superinfection based on influenza A (H1N1) pneumonia in a heart-lung transplant recipient.
    Yildirim Y, Pecha S, Sill B, Deuse T, Reichenspurner H| | PubMed
  81. Concomitant transcatheter aortic valve and left ventricular assist device implantation.
    Baum C, Seiffert M, Treede H, Reichenspurner H, Deuse T| | PubMed
  82. Late profound muscle weakness following heart transplantation due to Danon disease.
    Van Der Starre P, Deuse T, Pritts C, Brun C, Vogel H, Oyer P| | PubMed
  83. Significant reduction of acute cardiac allograft rejection by selective janus kinase-1/3 inhibition using R507 and R545.
    Deuse T, Hua X, Taylor V, Stubbendorff M, Baluom M, Chen Y, Park G, Velden J, Streichert T, Reichenspurner H, Robbins RC, Schrepfer S| | PubMed
  84. Clinical and functional correlates of early microvascular dysfunction after heart transplantation.
    Haddad F, Khazanie P, Deuse T, Weisshaar D, Zhou J, Nam CW, Vu TA, Gomari FA, Skhiri M, Simos A, Schnittger I, Vrotvec B, Hunt SA, Fearon WF| | PubMed
  85. Successful extracorporeal membrane oxygenation weaning after cardiac resynchronization therapy device implantation in a patient with end-stage heart failure.
    Pecha S, Yildirim Y, Reichenspurner H, Deuse T| | PubMed
  86. Human internal mammary artery (IMA) transplantation and stenting: a human model to study the development of in-stent restenosis.
    Hua X, Deuse T, Michelakis ED, Haromy A, Tsao PS, Maegdefessel L, Erben RG, Bergow C, Behnisch BB, Reichenspurner H, Robbins RC, Schrepfer S| | PubMed
  87. Cardiac paraganglioma: diagnostic and surgical challenges.
    Huo JL, Choi JC, DeLuna A, Lee D, Fleischmann D, Berry GJ, Deuse T, Haddad F| | PubMed
  88. Human leukocyte antigen I knockdown human embryonic stem cells induce host ignorance and achieve prolonged xenogeneic survival.
    Deuse T, Seifert M, Phillips N, Fire A, Tyan D, Kay M, Tsao PS, Hua X, Velden J, Eiermann T, Volk HD, Reichenspurner H, Robbins RC, Schrepfer S| | PubMed
  89. Immunobiology of naïve and genetically modified HLA-class-I-knockdown human embryonic stem cells.
    Deuse T, Seifert M, Phillips N, Fire A, Tyan D, Kay M, Tsao PS, Hua X, Velden J, Eiermann T, Volk HD, Reichenspurner H, Robbins RC, Schrepfer S| | PubMed
  90. Surgical technique of lower lobe lung transplantation.
    Deuse T, Sill B, von Samson P, Yildirim Y, Kugler C, Oldigs M, Klose H, Meierling S, Rabe KF, Reichenspurner H| | PubMed
  91. Bioluminescence imaging for assessment of immune responses following implantation of engineered heart tissue (EHT).
    Conradi L, Pahrmann C, Schmidt S, Deuse T, Hansen A, Eder A, Reichenspurner H, Robbins RC, Eschenhagen T, Schrepfer S| | PubMed
  92. Minimally invasive resection of a right atrial mass in a cardiac transplant recipient: a case report.
    Conradi L, Deuse T, Treede H, Seiffert M, Adam M, Koelble K, Costard-Jaeckle A, Wagner FM, Reichenspurner H| | PubMed
  93. Antibody response after a single dose of an AS03-adjuvanted split-virion influenza A (H1N1) vaccine in heart transplant recipients.
    Meyer S, Adam M, Schweiger B, Ilchmann C, Eulenburg C, Sattinger E, Runte H, Schlüter M, Deuse T, Reichenspurner H, Costard-Jäckle A| | PubMed
  94. Orthotopic aortic transplantation: a rat model to study the development of chronic vasculopathy.
    Stubbendorff M, Deuse T, Hammel A, Robbins RC, Reichenspurner H, Schrepfer S| | PubMed
  95. Transcatheter aortic valve implantation in a heart transplant recipient: a case report.
    Seiffert M, Meyer S, Franzen O, Conradi L, Baldus S, Schirmer J, Deuse T, Costard-Jaeckle A, Reichenspurner H, Treede H| | PubMed
  96. Immunogenicity and immunomodulatory properties of umbilical cord lining mesenchymal stem cells.
    Deuse T, Stubbendorff M, Tang-Quan K, Phillips N, Kay MA, Eiermann T, Phan TT, Volk HD, Reichenspurner H, Robbins RC, Schrepfer S| | PubMed
  97. Sustained inhibition of epsilon protein kinase C inhibits vascular restenosis after balloon injury and stenting.
    Deuse T, Koyanagi T, Erben RG, Hua X, Velden J, Ikeno F, Reichenspurner H, Robbins RC, Mochly-Rosen D, Schrepfer S| | PubMed
  98. Review of heart-lung transplantation at Stanford.
    Deuse T, Sista R, Weill D, Tyan D, Haddad F, Dhillon G, Robbins RC, Reitz BA| | PubMed
  99. Non-volume-loaded heart provides a more relevant heterotopic transplantation model.
    Tang-Quan KR, Bartos J, Deuse T, Churchill E, Schäfer H, Reichenspurner H, Mochly-Rosen D, Robbins RC, Schrepfer S| | PubMed
  100. Heterotopic and orthotopic tracheal transplantation in mice used as models to study the development of obliterative airway disease.
    Hua X, Deuse T, Tang-Quan KR, Robbins RC, Reichenspurner H, Schrepfer S| | PubMed
  101. Asymptomatic infection with novel influenza A/H1N1 virus in a heart transplant recipient.
    Meyer S, Ilchmann C, Adam M, Sattinger E, Siamkouris D, Arunagirinathan U, Deuse T, Wagner FM, Reichenspurner H, Costard-Jaeckle A| | PubMed
  102. Mechanisms behind local immunosuppression using inhaled tacrolimus in preclinical models of lung transplantation.
    Deuse T, Blankenberg F, Haddad M, Reichenspurner H, Phillips N, Robbins RC, Schrepfer S| | PubMed
  103. Changing trends in infectious disease in heart transplantation.
    Haddad F, Deuse T, Pham M, Khazanie P, Rosso F, Luikart H, Valantine H, Leon S, Vu TA, Hunt SA, Oyer P, Montoya JG| | PubMed
  104. LAD-ligation: a murine model of myocardial infarction.
    Kolk MV, Meyberg D, Deuse T, Tang-Quan KR, Robbins RC, Reichenspurner H, Schrepfer S| | PubMed
  105. Alternative technique for salvage of donor lungs with insufficient atrial cuffs.
    Yarbrough WM, Bates MJ, Deuse T, Tang DG, Robbins RC, Reitz BA, Mallidi HR| | PubMed
  106. Hepatocyte growth factor or vascular endothelial growth factor gene transfer maximizes mesenchymal stem cell-based myocardial salvage after acute myocardial infarction.
    Deuse T, Peter C, Fedak PW, Doyle T, Reichenspurner H, Zimmermann WH, Eschenhagen T, Stein W, Wu JC, Robbins RC, Schrepfer S| | PubMed
  107. Imaging in-stent restenosis: an inexpensive, reliable, and rapid preclinical model.
    Deuse T, Ikeno F, Robbins RC, Schrepfer S| | PubMed
  108. Heart-lung transplantation in situs inversus totalis.
    Deuse T, Reitz BA| | PubMed
  109. Right ventricular dysfunction predicts poor outcome following hemodynamically compromising rejection.
    Haddad F, Fisher P, Pham M, Berry G, Weisshaar D, Kuppahally S, Vrtovec B, Deuse T, Virani S, Fearon W, Valantine H, Hunt S| | PubMed
  110. A novel JAK3 inhibitor, R348, attenuates chronic airway allograft rejection.
    Velotta JB, Deuse T, Haddad M, Masuda E, Park G, Carroll D, Taylor V, Robbins RC, Schrepfer S| | PubMed
  111. Heart transplantation in situs inversus totalis.
    Deuse T, Reitz BA| | PubMed
  112. Twenty-year survivors of heart transplantation at Stanford University.
    Deuse T, Haddad F, Pham M, Hunt S, Valantine H, Bates MJ, Mallidi HR, Oyer PE, Robbins RC, Reitz BA| | PubMed
  113. Novel immunosuppression: R348, a JAK3- and Syk-inhibitor attenuates acute cardiac allograft rejection.
    Deuse T, Velotta JB, Hoyt G, Govaert JA, Taylor V, Masuda E, Herlaar E, Park G, Carroll D, Pelletier MP, Robbins RC, Schrepfer S| | PubMed
  114. Prevention and inhibition but not reversion of chronic allograft vasculopathy by FK778.
    Deuse T, Hoyt G, Koyanagi T, Robbins RC, Schrepfer S| | PubMed
  115. Introducing the first polymer-free leflunomide eluting stent.
    Deuse T, Erben RG, Ikeno F, Behnisch B, Boeger R, Connolly AJ, Reichenspurner H, Bergow C, Pelletier MP, Robbins RC, Schrepfer S| | PubMed
  116. Fluoroscopy to assess late heart and lung perforation by a permanent ventricular pacemaker lead. A case complicated by isolated hemothorax.
    Mortensen K, Aydin MA, Goldmann B, Deuse T, Willems S, Ventura R| | PubMed
  117. Effect of inhaled tacrolimus on cellular and humoral rejection to prevent posttransplant obliterative airway disease.
    Schrepfer S, Deuse T, Reichenspurner H, Hoffmann J, Haddad M, Fink J, Fischbein MP, Robbins RC, Pelletier MP| | PubMed
  118. Is the malononitrilamide FK778 better for the prevention of acute or chronic rejection?
    Deuse T, Schrepfer S, Pelletier MP, Fischbein MP, Robbins RC, Reichenspurner H| | PubMed
  119. Stem cell transplantation: the lung barrier.
    Schrepfer S, Deuse T, Reichenspurner H, Fischbein MP, Robbins RC, Pelletier MP| | PubMed
  120. Techniques for experimental heterotopic and orthotopic tracheal transplantations - When to use which model?
    Deuse T, Schrepfer S, Reichenspurner H, Hoyt G, Fischbein MP, Robbins RC, Pelletier MP| | PubMed
  121. Simplified protocol to isolate, purify, and culture expand mesenchymal stem cells.
    Schrepfer S, Deuse T, Lange C, Katzenberg R, Reichenspurner H, Robbins RC, Pelletier MP| | PubMed
  122. Experimental orthotopic tracheal transplantation: The Stanford technique.
    Schrepfer S, Deuse T, Hoyt G, Sheikh AY, Hoffmann J, Reichenspurner H, Robbins RC, Pelletier MP| | PubMed
  123. FK778 in experimental xenotransplantation: a detailed analysis of drug efficacy.
    Schrepfer S, Deuse T, Koch-Nolte F, Krieger T, Haddad M, Schäfer H, Pelletier MP, Robbins RC, Reichenspurner H| | PubMed
  124. Inhibition of restenosis development after mechanical injury: a new field of application for malononitrilamides?
    Schrepfer S, Deuse T, Sultan KR, Haddad M, Böger R, Münzel T, Schäfer H, Pelletier MP, Robbins RC, Reichenspurner H| | PubMed
  125. The selective estrogen receptor-beta agonist biochanin A shows vasculoprotective effects without uterotrophic activity.
    Schrepfer S, Deuse T, Münzel T, Schäfer H, Braendle W, Reichenspurner H| | PubMed
  126. Heparins increase endothelial nitric oxide bioavailability by liberating vessel-immobilized myeloperoxidase.
    Baldus S, Rudolph V, Roiss M, Ito WD, Rudolph TK, Eiserich JP, Sydow K, Lau D, Szöcs K, Klinke A, Kubala L, Berglund L, Schrepfer S, Deuse T, Haddad M, Risius T, Klemm H, Reichenspurner HC, Meinertz T, Heitzer T| | PubMed
  127. FK778: new cellular and molecular mechanisms of action.
    Schrepfer S, Deuse T, Koch-Nolte F, Detter C, Reichenspurner H| | PubMed
  128. Sirolimus and FK778: a comparison of two anti-proliferative immunosuppressants for prevention of experimental obliterative airway disease.
    Deuse T, Schrepfer S, Koch-Nolte F, Haddad M, Schäfer H, Detter C, Reichenspurner H| | PubMed
  129. Tracheal allograft transplantation in rats: the role of different immunosuppressants on preservation of respiratory epithelium.
    Schrepfer S, Deuse T, Sydow K, Schäfer H, Detter C, Reichenspurner H| | PubMed
  130. The phytoestrogen biochaninA weakens acute cardiac allograft rejection without affecting the reproductive system.
    Schrepfer S, Deuse T, Schäfer H, Koch-Nolte F, Braendle W, Reichenspurner H| | PubMed
  131. FK778 and tacrolimus prevent the development of obliterative airway disease after heterotopic rat tracheal transplantation.
    Deuse T, Schrepfer S, Koch-Nolte F, Haddad M, Schwedhelm E, Böger R, Schäfer H, Detter C, Reichenspurner H| | PubMed
  132. FK778, a novel immunosuppressive agent, reduces early adhesion molecule up-regulation and prolongs cardiac allograft survival.
    Schrepfer S, Deuse T, Schäfer H, Reichenspurner H| | PubMed
  133. Video and robotic-assisted minimally invasive mitral valve surgery: a comparison of the Port-Access and transthoracic clamp techniques.
    Reichenspurner H, Detter C, Deuse T, Boehm DH, Treede H, Reichart B| | PubMed
  134. FK778 attenuates lymphocyte-endothelium interaction after cardiac transplantation: in vivo and in vitro studies.
    Deuse T, Schrepfer S, Schäfer H, Koch-Nolte F, Schwedhelm E, Böger RH, Reichenspurner H| | PubMed
  135. The interaction between FK778 and tacrolimus in the prevention of rat cardiac allograft rejection is dose dependent.
    Deuse T, Schrepfer S, Reichenspurner H| | PubMed
  136. Immunosuppression with FK778 and mycophenolate mofetil in a rat cardiac transplantation model.
    Deuse T, Schrepfer S, Reichenspurner H| | PubMed
  137. Successful resection of a symptomatic right ventricular lipoma.
    Schrepfer S, Deuse T, Detter C, Treede H, Koops A, Boehm DH, Willems S, Lacour-Gayet F, Reichenspurner H| | PubMed
  138. Robotically assisted coronary artery bypass surgery with the ZEUS telemanipulator system.
    Boehm DH, Detter C, Arnold MB, Deuse T, Reichenspurner H| | PubMed
  139. Correlation between mononuclear infiltration and changes in VASP phosphorylation patterns after heterotopic cardiac transplantation in the rat.
    Deuse T, Lange V, Schrepfer S, Eigenthaler M, Reichart B, Walter U, Elert O| | PubMed
  140. Early and midterm results after coronary artery bypass grafting with and without cardiopulmonary bypass: which patient population benefits the most?
    Deuse T, Detter C, Samuel V, Boehm DH, Reichenspurner H, Reichart B| | PubMed
  141. New technique for chest opening in mice: U-sternotomy.
    Schrepfer S, Deuse T, Reichenspurner H| | PubMed
  142. Midterm results and quality of life after minimally invasive vs. conventional aortic valve replacement.
    Detter C, Deuse T, Boehm DH, Reichenspurner H, Reichart B| | PubMed
  143. Comparison of two stabilizer concepts for off-pump coronary artery bypass grafting.
    Detter C, Deuse T, Christ F, Boehm DH, Reichenspurner H, Reichart B| | PubMed
  144. Robotically-assisted coronary artery surgery with and without cardiopulmonary bypass - from first clinical use to endoscopic operation.
    Detter C, Boehm DH, Reichenspurner H, Deuse T, Arnold M, Reichart B| | PubMed
  145. Effect of hemodynamics on graft rejection in the heterotopic heart transplantation model.
    Lange V, Gassel AM, Deuse T, Ulrichs K, Silber RE| | PubMed