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The Transplant and Stem Cell Immunobiology (TSI) Laboratory
UCSF Department of Surgery
The Transplant and Stem Cell Immunobiology (TSI) Laboratory
UCSF Department of Surgery
The Transplant and Stem Cell Immunobiology (TSI) Laboratory
UCSF Department of Surgery
The Transplant and Stem Cell Immunobiology (TSI) Laboratory
UCSF Department of Surgery
Our Research
Stem cell transplantation is a quickly developing area of research with the goal of...
TSI Lab Space Medicine With new funding from the National Aeronautics and Space Administration (NASA), the TSI Lab
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Stem cell transplantation is a quickly developing area of research with the goal of replacing, regenerating, or reinvigorating
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Organ transplantation is often the only clinical option available for treating certain types of cardiovascular disease. While frequently
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Featured Publications
- Hu X, White K, Olroyd AG, DeJesus R, Dominguez A, Dowdle WE, Friera AM, Young A, Wells F, Chu EY, McGill TJ, Lin A, Egenberger K, Gagnon A, Rukstalis JM, Hogrebe NJ, Gattis C, Basco R, Millman JR, Kievit P, Davis MM, Lanier LL, Connolly AJ, Deuse T, Schrepfer S. Hypoimmune rhesus macaque induced pluripotent stem cells achieve long-term survival in fully immunocompetent allogeneic recipients. Nat Biotechnol. 2023; doi: 10.1038/s41587-023-01784-x.
- Hu X, Gattis C, Olroyd AG, Friera AM, White K, Young C, Basco R, Lamba M, Wells F, Ankala R, Dowdle WE, Lin A, Egenberger K, Rukstalis JM, Millman JR, Connolly AJ, Deuse T, Schrepfer S. Human hypoimmune primary pancreatic islets avoid rejection and autoimmunity and alleviate diabetes in allogeneic humanized mice. Sci Transl Med. 2023 Apr 12;15(691):eadg5794. doi: 10.1126/scitranslmed.adg5794.
- Hu X, Manner K, DeJesus R, White K, Gattis C, Ngo P, Bandoro C, Tham E, Chu EY, Young C, Wells F, Basco R, Friera A, Kangeyan D, Beauchesne P, Dowdle WE, Deuse T, Fry TJ, Foster AE, Schrepfer S. Hypoimmune anti-CD19 chimeric antigen receptor T cells provide lasting tumor control in fully immunocompetent allogeneic humanized mice. Nat Commun. 2023 Apr 10;14(1):2020. doi: 10.1038/s41467-023-37785-2.
- Gravina A, Tediashvili G, Rajalingam R, Quandt Z, Deisenroth C, Schrepfer S, Deuse T. CD64 expression protects cell therapeutics from antibody-mediated rejection. Nat Biotechnol 2023 Jan 2. doi: 10.1038/s41587-022-01540-7.
- Deuse T, Tediashvili G, Hu X, Gravina A, Tamenang A, Wang D, Connolly A, Mueller C, Mallavia B, Looney MR, Alawi A, Lanier LL, Schrepfer S. Hypoimmune iPSC-derived cell products treat cardiovascular and pulmonary diseases in immunocompetent allogeneic mice. PNAS 2021;118(28):e2022091118.
- Deuse T, Hu X, Agbor-Enoh S, Jang MK, Alawi M, Saygi C, Gravina A, Tediashvili G, Nguyen VQ, Liu Y, Valantine H, Lanier LL, Schrepfer S. The SIRPα-CD47 immune checkpoint in NK cells. J Exp Med. 2021;218(3):e20200839.
- Deuse T, Hu X, Gravina A, Wang D, Tediashvili G, De C, WO. T, Wahl A, Garcia J, Davis MM, Lanier LL, Schrepfer S. Hypo-immunogenic iPSC-derivatives show long-term survival in fully immunocompetent allogeneic recipients. Nat Biotechnol. 2019;37(3):252-258. doi: 10.1038/s41587-019-0016-3.