TSILab - Homepage
Principal Investigators
Sonja Schrepfer, MD, PhD
Professor of Surgery, UCSF
Division of Cardiothoracic Surgery
Director, TSI Lab
Tobias Deuse, MD
Professor of Surgery, UCSF
Division of Cardiothoracic Surgery
The Julien I.E. Hoffman, M.D. Endowed Chair in Cardiac Surgery
Director, Minimally-invasive Cardiac Surgery
Surgical Director, Transcatheter Valve Program
Principal Investigator, TSI lab
Stem Cell & Transplant Immunobiology, Cardiovascular Disease, Space Medicine
The Transplant and Stem Cell Immunobiology (TSI) Laboratory uses multiple research directions to answer complex questions about stem cell therapy, heart and lung transplantation, and cardiovascular disease. Our laboratory focuses on the immunogenicity of allogeneic stem cells, tissues, and organs, and is interested in designing methods to prevent immunological recognition and rejection of such materials.
We are also interested in better understanding and preventing mechanisms that result in cardiovascular disease. With topics that range from basic science (e.g. identifying novel molecules involved in pluripotent stem cell immunogenicity) to translational medicine (e.g. developing drugs that may be useful in reducing myointimal hyperplasia), we take a wide-angle approach to our research.
Currently, we are involved in exciting cardiovascular research funded by the National Aeronautics and Space Administration (NASA). In addition to our excellent team at UCSF, we also work closely both scientifically and collaboratively with our sister laboratory in Hamburg, Germany.
Featured Publications
- Leukotriene B4: A potential mediator and biomarker for cardiac allograft vasculopathy.
2024 | PubMed - Hypoimmune islets achieve insulin independence after allogeneic transplantation in a fully immunocompetent non-human primate.
2024 | PubMed - Synthetic immune checkpoint engagers protect HLA-deficient iPSCs and derivatives from innate immune cell cytotoxicity.
2023 | PubMed - Hypoimmune induced pluripotent stem cells survive long term in fully immunocompetent, allogeneic rhesus macaques.
2023 | PubMed - Human hypoimmune primary pancreatic islets avoid rejection and autoimmunity and alleviate diabetes in allogeneic humanized mice.
2023 | PubMed